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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HAGH All Species: 38.79
Human Site: T279 Identified Species: 71.11
UniProt: Q16775 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q16775 NP_001035517.1 308 33806 T279 F M R V R E K T V Q Q H A G E
Chimpanzee Pan troglodytes XP_510739 282 31321 T253 F M R V R E K T V Q Q H A G K
Rhesus Macaque Macaca mulatta XP_001090907 308 33886 T279 F M R V R E K T V Q Q H A R E
Dog Lupus familis XP_537013 309 33857 T280 F M R V R E K T V Q Q H A G E
Cat Felis silvestris
Mouse Mus musculus Q99KB8 309 34066 T280 F M R V K E K T V Q Q H A G E
Rat Rattus norvegicus O35952 309 34091 T280 F M R V K E K T V Q Q H A G E
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q5ZI23 310 34206 T281 F M R V R E K T V Q E H A G E
Frog Xenopus laevis NP_001089873 260 29031 D240 Q E H A G E Q D P I S T M G A
Zebra Danio Brachydanio rerio Q6P963 303 33787 S274 F M R V R E K S V L E H A G T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_730568 348 38839 T321 F M R V H E A T V Q K H A G G
Honey Bee Apis mellifera XP_623458 288 32956 S262 F M R V H E Q S V M D H T E Q
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_783848 258 28463 S237 S I Q D H V G S T E P I E V M
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O24496 258 28773 L237 K P E I Q E K L G C K S P I D
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 90.2 96.4 86.4 N.A. 87.3 84.7 N.A. N.A. 74.8 68.5 71.4 N.A. 48.5 52.2 N.A. 51.9
Protein Similarity: 100 91.2 98.6 93.5 N.A. 94.8 93.1 N.A. N.A. 86.7 78.5 84 N.A. 64.3 67.8 N.A. 65.5
P-Site Identity: 100 93.3 93.3 100 N.A. 93.3 93.3 N.A. N.A. 93.3 13.3 73.3 N.A. 73.3 46.6 N.A. 0
P-Site Similarity: 100 100 93.3 100 N.A. 100 100 N.A. N.A. 100 20 86.6 N.A. 80 66.6 N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. 45.4 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 59.7 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 40 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 8 0 0 8 0 0 0 0 0 70 0 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % C
% Asp: 0 0 0 8 0 0 0 8 0 0 8 0 0 0 8 % D
% Glu: 0 8 8 0 0 93 0 0 0 8 16 0 8 8 47 % E
% Phe: 77 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 8 0 8 0 8 0 0 0 0 70 8 % G
% His: 0 0 8 0 24 0 0 0 0 0 0 77 0 0 0 % H
% Ile: 0 8 0 8 0 0 0 0 0 8 0 8 0 8 0 % I
% Lys: 8 0 0 0 16 0 70 0 0 0 16 0 0 0 8 % K
% Leu: 0 0 0 0 0 0 0 8 0 8 0 0 0 0 0 % L
% Met: 0 77 0 0 0 0 0 0 0 8 0 0 8 0 8 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 8 0 0 0 0 0 0 8 0 8 0 8 0 0 % P
% Gln: 8 0 8 0 8 0 16 0 0 62 47 0 0 0 8 % Q
% Arg: 0 0 77 0 47 0 0 0 0 0 0 0 0 8 0 % R
% Ser: 8 0 0 0 0 0 0 24 0 0 8 8 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 62 8 0 0 8 8 0 8 % T
% Val: 0 0 0 77 0 8 0 0 77 0 0 0 0 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _